Near-InfraredFluorescent Nanoprobe for Detecting Hydrogen Peroxide in Inflammation and Ischemic Kidney Injury

摘要

of main observation and conclusion In-situoverexpressed hydrogen peroxide could serve as a biomarker for inflammation and ischemic kidney injury. Herein, a nanoprobe was developed for assay of hydrogen peroxide. The nanoprobe (TA-TPABQ) was formedviathe boronate ester groups between the hydrophilic tannic acid and the boric-acid-containing compound (TPABQ) as well as the hydrophobic interactions. The probe with good photostability shows good sensitivity and selectivity towards H2O2. The probe was adopted for identifying endogenous and exogenous H2O2 in living cells. Moreover, the probe was utilized forin vivoimaging experiments in acute abdomina and ankle inflammation mouse models as well as acute renal ischemia mouse model.

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