Berberine improves central memory formation of CD8D T cells: Implications for design of natural product-based vaccines

作者：Li, Mingyan; Wang, Yaling; Zhang, Lingzhi; Gao, Changxing; Jiang, Jiandong^*; Zhu, Qing^*

来源：Acta Pharmaceutica Sinica B, 2023, 13(5): 2259-2268.

DOI：10.1016/j.apsb.2023.02.017

• T cell priming
• Central memory
• Vaccine design
• Naturally occurring
• compound
• Berberine
• CD8 thorn T cell
• AMPK
• Stat5

Berberine (BBR) as one of the most effective natural products has been increasingly used to treat various chronic diseases due to its immunosuppressive/tolerogenic activities. However, it is un-known if BBR can be applied without abrogating the efforts of vaccination. Here we show that priming of CD8 thorn T cells in the presence of BBR lead to improved central memory formation (Tcm) with substan-tially reduced effector proliferation, primarily orchestrated through activation of AMPK and Stat5. Tcm derived from vaccinated mice fed with BBR were able to adoptively transfer protective immunity to nai center dot ve recipients. Vaccination of BBR-fed mice conferred better memory protection against infection without losing immediate effector efficacy, suggesting appreciable benefits from using BBR in vaccination. Thus, our study may help to lay the groundwork for mechanistic understanding of the immunomodulatory ef-fects of natural products and their potential use as adjuvant that allows the design of novel vaccines with more desirable properties. (c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

• 单位
  云南大学; 中国医学科学院北京协和医院