Lower Dorsal Lateral Prefrontal Cortex Functional Connectivity in Late-Life Depression With Suicidal Ideation

作者：Lin, Gaohong; Chen, Ben; Yang, Mingfeng; Wu, Zhangying; Qiu, Kaijie; Zhang, Min; Wang, Qiang; Zhang, Si; Lao, Jingyi; Zeng, Yijie; Ning, Yuping; Zhong, Xiaomei^*

来源：American Journal of Geriatric Psychiatry, 2023, 31(11): 905-915.

DOI：10.1016/j.jagp.2023.05.006

• Suicidal ideation
• late-life depression
• resting-state functional connectivity
• functional magnetic resonance
• imaging
• dorsal lateral prefrontal cortex

Objective: The dorsal lateral prefrontal cortex (DLPFC) has been identified as a neuromodulation target for alleviating suicidal ideation. Dysfunctional DLPFC has been implicated in suicidality in depression. This study aimed to investigate the functional connectivity (FC) of the DLPFC in late-life depression (LLD) with suicidal ideation. Methods: Resting-state functional magnetic resonance imag-ing (fMRI) data from 32 LLD patients with suicidal ideation (LLD-S), 41 LLD patients without suicidal ideation (LLD-NS), and 54 healthy older adults (HOA) were analyzed using DLPFC seed-based FC analyses. Group differences in FC were examined, and machine learning was applied to explore the potential of DLPFC-FCfor classifying LLD-S from LLD-NS. Results: Abnormal DLPFC-FC pat-terns were observed in LLD-S, characterized by lower connectivity with the angular gyrus, precuneus, and superior frontal gyrus compared to LLD-NS and healthy controls. A classification model based on the identified DLPFC-FC achieved an accuracy of 75%. Conclusion: The lower FC of DLPFC networks may contribute to the neurobiological mechanism of suicidal ideation in late-life depression. These findings may facilitate suicide prevention for LLD by providing potential neuroimaging markers and network-based neuromodulation targets. However, further confirmation with larger sample sizes and experimental designs is warranted.

• 单位
  广州医学院; 南方医科大学; 1