Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery

摘要

The first poly(beta-amino) esters (P beta AEs) were synthesized more than 40 years ago. Since 2000, P beta AEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of P beta AEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, P beta AEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of P beta AEs and summarizes the progress of each type of P beta AE for gene delivery. The review focuses in particular on the rational design of P beta AE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of P beta AEs.

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