面向组合逻辑的 DNA 计算

作者：Zhang Chuan^*; Zhong Zhiwei; Zhuang Yuchen; Fang Chongzhou; Lu Yuxiang; Jin Jiejun; Ge Lulu; Shen Ziyuan; Zhang Zaichen; You Xiaohu

来源：Scientia Sinica Informationis, 2019, 49(7): 819-837.

DOI：10.1360/N112019-00007

• chemical reaction networks
• combinational logic
• DNA computing
• DNA strand displacement reactions
• synthetic biology

With the progressive scale-down of semiconductor feature size, people are looking forward to More Moore and More than Moore. Thus, people are trying to devise a feasible transfer from silicon to molecular computing to offer a possible alternative implementation process. Such a transfer is based on bio-based module programming with computer-like logic, aimed at realizing the Turing machine. DNA-based combinational logic is inevitably the first step that we have taken to accomplish this. This timely overview paper introduces combinational logic separately synthesized in DNA computing from both analog and digital perspectives. State-of-the-art research progress is summarized herein for interested readers to quickly understand DNA computing, initiate discussion on existing techniques, and inspire innovative solutions. We hope this review paves the way for future DNA computing synthesis.