Advances in Continuous Flow Fluorination Reactions

摘要

Fluorination reactions are important in constructing organofluorine motifs, which contribute to favorable biological properties in pharmaceuticals and agrochemicals. However, fluorination reagents and reactions are associated with various problems, such as their hazardous nature, high exothermicity, and poor selectivity and scalability. Continuous flow has emerged as a transformative technology to provide many advantages relative to batch syntheses. This review article summarizes recent continuous flow techniques that address the limitations and challenges of fluorination reactions. Approaches based on different flow techniques are discussed, including gas-liquid reactions, packed-bed reactors, in-line purifications, streamlined multistep synthesis, large-scale reactions well as flow photoredox- and electrocatalysis. @@@ Fluorination reactions are important in constructing organofluorine motifs in pharmaceuticals and agrochemicals, but they pose challenges due to their hazardous nature, high exothermicity, and limited selectivity and scalability. This review explores recent continuous flow techniques that addressed challenges of fluorination reactions, including gas-liquid reactions, packed-bed reactors, in-line purifications, reaction telescoping, large-scale reactions as well as flow photoredox- and electrocatalysis.image

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