In Situ Embedding Hydrogen-Bonded Organic Frameworks Nanocrystals in Electrospinning Nanofibers for Ultrastable Broad-Spectrum Antibacterial Activity

作者：Wang, Yao; Cao, Ran^*; Wang, Chen; Song, Xiyu; Wang, Ruina; Liu, Jiacun; Zhang, Mengmeng; Huang, Junyi; You, Tingting; Zhang, Yihua; Yan, Dapeng; Han, Wendong^*; Yan, Lan; Xiao, Jisheng^*; Li, Peng^*

来源：Advanced Functional Materials, 2023, 33(20).

DOI：10.1002/adfm.202214388

• antibacterial nanofibers
• electrospinning
• hydrogen-bonded organic frameworks
• nanocrystals
• singlet oxygen generation

In the event of a public health crisis, highly effective and sustainable antimicrobial materials and equipment will be urgently needed. Here, the preparation is reported by electrospinning of broad-spectrum antibacterial nanofibers embedded in a photoactive hydrogen-bonded organic framework (HOF) of rod-like nanocrystals approximate to 60 nm in length. The resulting HOF@PVDF-HFP nanofibers maintain excellent tensile and breathability characteristics while shielding HOF nanocrystals against acid and alkali corrosion. A series of nanofibers embedded with different amounts and types of HOF nanocrystals are prepared to optimize their efficiency of singlet oxygen (O-1(2)) generation. The 0.5 wt.% HOF-101-F@PVDF-HFP nanofibers exhibit the most efficient O-1(2) generation that is enhanced by a factor of almost 2 when compared with the HOF-101-F microcrystalline powder. The HOF@PVDF-HFP nanofibers are demonstrated to highly effectively kill pathogens, including viruses, bacteria, and fungi in 30 min under ambient light conditions.

• 单位
  南方医科大学; 复旦大学