Tannic Acid-Assisted Synthesis of Biodegradable and Antibacterial Mesoporous Organosilica Nanoparticles Decorated with Nanosilver

作者：Zhang, Yue; He, Yan; Shi, Chengxin; Sun, Madi; Yang, Chao^*; Li, Haijun; Chen, Fangman; Chang, Zhimin; Zheng, Xiao; Wang, Zheng; Dong, Wen-fei^*; She, Junjun; Shao, Dan^*

来源：ACS Sustainable Chemistry & Engineering, 2020, 8(3): 1695-+.

DOI：10.1021/acssuschemeng.9b07576

• mesoporous organosilica nanoparticles
• silver nanoparticle
• GSH-responsive release
• antibacterial activity
• biodegradable

Metal/silica nanoparticles (NPs) have long been used as antibacterial substitutes; however, fabrication of a degradable carrier for achieving sustained release profile, high bactericidal efficacy, and good biocompatibility is still a challenge. Herein, we fabricated nanosilver-decorated biodegradable mesoporous organosilica nanoparticles (MONs) using a biocompatible natural polyphenol, tannic acid (TA), as not only a nonsurfactant template to form MONs but also a reducible agent to generate nanosilvers. Such a straightforward and green one-pot method does not need prior synthesis of silver NPs, removal of template, and use of toxic reducing agents. The resulting Ag-MONs with a well-distributed nanosilver exhibited a matrix-degradation-based silver ions release in response to glutathione (GSH), resulting in a stronger antibacterial effect with nondegradable Ag-mesoporous silica nanoparticles (MSNs), Ag NPs, and silver nitrate on Escherichia coli and Staphylococcus aureus. Moreover, Ag-MONs show better biocompatibility than the Ag NPs and silver nitrate at the same silver dose. Our findings have provided a facile and economical route to fabricate nanosilver-decorated biodegradable mesoporous organosilica nanoparticles. These nanoparticles showed promising applications in the fields of biomedicine and catalysis.

• 单位
  西安交通大学; 1; 吉林大学; 中国科学院; 郑州大学