Early music exposure modifies GluR2 protein expression in rat auditory cortex and anterior cingulate cortex

作者：Junbai Li; Sanchez M; Xia Z; Rico Bautista E; Cao X; Castro DJ; Correa RG; Chen L; Yu J; Bobkov A; Ruvolo V; Andreeff M; Oshima RG; Matsuzawa SI; Reed JC; Zhang XK; Hansel D; Wolf DA; Dawson MI

来源：11NEUROSCIENCE LETTERS, 2007, 11420(112): 11179-11183.

DOI：29296278

• 11rat
• auditory cortex
• anterior cingulate cortex
• music exposure
• GluR2
• western blotting

GluR2, a major subunit in AMPA receptor, plays an important role in brain functional activity. We studied the effect of music exposure during development on the expression level of GluR2 proteins in the auditory cortex (AC) and anterior cingulate cortex (ACC) of SD rats. Rats were divided into three groups, Music1 (exposed to Nostalgy) group, Music2 (exposed to Wishmaster) group, and control (no music exposure) group. For music exposure groups, rats were exposed to music from postnatal day (PND) 14, and the expression levels of GluR2 proteins were determined at PND 28, 42 and 56. For the control group, the expression levels of GluR2 proteins were determined at PND1, 3, 5, 7, 9, 11, 14, 21, 28, 42, and 56. Results showed an age-dependent expression of GluR2 proteins in control rats. In AC, exposure to Music2 dramatically increased the expression of GluR2, while exposure to Music I had no effect. In ACC, we found remarkable discrepancies in time-dependent expression of GluR2 between music exposed rats and control rats. These results indicate that exposure to music can modify the expression level of GluR2 protein in AC and ACC.

• 单位
  华东师范大学