Transition metal-free annulative vinylene transfer via the 1,3-dipolar reaction of N-ylides: access to benzo-fused indolizines

作者：Zhao, Limin; Li, Wen; Liu, Jiali; Ni, Linying; Liu, Zhihao; Shen, Hao; Cao, Hua; Liu, Xiang^*

来源：Organic and Biomolecular Chemistry, 2022, 20(48): 9604-9608.

DOI：10.1039/d2ob01846b

• CARBONATE
• CYCLIZATION
• STRATEGY
• C1

An efficient metal-free annulative vinylene transfer protocol for the synthesis of benzo-fused indolizines via 1,3-dipolar cycloadditions of N-ylides with vinylene carbonate has been developed. Vinylene carbonate serves as an acetylene surrogate without any external oxidant involved. This transformation leads to the direct construction of versatile benzo-fused indolizine derivatives in moderate to good yields.

• 单位
  广东药学院