[Analysis of the test results of HBV serum markers and HBV DNA of the neonates born to HBsAg-positive mothers].

Authors：Wang M C^*; Xu A F; Zhang Y L; Xu D M

Source：Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2011, 25(6): 445-447.

To observe the HBV serum markers and HBV DNA expressions of the neonates born to the HBsAg-positive mothers. By detecting serum immunity markers of hepatitis B virus (5 items) and serum HBV DNA of 283 neonates (a pair of twins) born to 282 HBsAg-positive mothers. 12 patterns emerge from the study of the hepatitis B serum markers of 283 neonates. Topping the list is the combination of HBeAg and anti-HBc positive accounting for 48.41 (137/283), followed by the combination of anti-HBe and anti-HBc positive accounting for 22.26 (62/283). The third highest combination is that of HBsAg, HBeAg and anti-HBc positive accounting for 12.37 (35/283). There are five combinations accounting for 16.61 (47/283), each with HBsAg-positive. No case is found of the five items all negative or only HBsAb positive. Five cases are detected of serum HBV DNA > or = 1 x 103 IU/ml accounting for 1.77. Neonates born to HBsAg-positive mothers display complex patterns of serum hepatitis B markers, the dominant pattern being the combination of HBeAg and anti-HBc positive. Cases of serum HBV DNA > or = 1 x 10(3) IU/ml are rare.