Nonenzymatic Electrochemical Sensing Platform Based on 2D Isomorphic Co/Ni-Metal-Organic Frameworks for Glucose Detection

作者：Wang, Xin-Ying; Yan, Xue-Xue; Wu, Ya-Pan^*; Wu, Xue-Qian; Yin, Ya-Meng; Li, Shuang; Zhang, Qichun; Liu, Bin; Li, Dong-Sheng^*

来源：Inorganic Chemistry, 2023, 62(26): 10256-10262.

DOI：10.1021/acs.inorgchem.3c01058

• SENSORS
• CU
• MOF
• NANOMATERIALS
• NANOSHEETS
• ELECTRODE

Two-dimensional metal-organic framework (MOF)crystallinematerials possess promising potential in the electrochemical sensingprocess owing to their tunable structures, high specific surface area,and abundant metal active sites; however, developing MOF-based nonenzymaticglucose (Glu) sensors which combine electrochemical activity and environmentalstability remains a challenge. Herein, utilizing the tripodic nitrogen-bridged1,3,5-tris(1-imidazolyl) benzene (TIB) linker, Co2+ andNi(2+), two 2D isomorphic crystalline materials, includingCo/Ni-MOF {[Co (TIB)]& BULL;2BF(4)} (CTGU-31)and {[Ni(TIB)]& BULL;2NO(3)} (CTGU-32), witha binodal (3, 6)-connected kgd topologicalnet were firstly synthesized and fabricated with conducting acetyleneblack (AB). When modified on a glassy carbon electrode, the optimizedAB/CTGU-32 (1:1) electrocatalyst demonstrated a higher sensitivityof 2.198 & mu;A & mu;M-1 cm(-2), a wider linear range from 10 to 4000 & mu;M, and a lower detectionlimit (LOD) value (0.09 & mu;M, S/N = 3) compared to previously MOF-based Glu sensors. Moreover, AB/CTGU-32(1:1) exhibited desirable stability for at least 2000 s during theelectrochemical process. The work indicates that MOF-based electrocatalystsare a promising candidate for monitoring Glu and demonstrate theirpotential for preliminary screening for diabetes. @@@ Two new 2D isomorphic CTGU-31 and CTGU-32were successfullysynthesized, and a nonenzymatic electrochemical sensor was fabricatedfor Glu-sensing. The AB/CTGU-32(1:1) sensor showed superior Glu-sensingperformance to most reported MOF-based sensors with superior sensitivityunder the near linear range. This work provides a useful strategyfor Glu detection and potential applications for preliminary screeningfor diabetes mellitus patients.