KRAS modulates immune infiltration levels and survival outcomes in patients with lung adenocarcinoma

作者：Li, Na; Tian, Yue; Liu, Xin; Pan, Ciming; Xue, Jian^*

来源：Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries, 2023, 102(52): e36597.

DOI：10.1097/MD.0000000000036597

• KRAS
• level of immune infiltration
• LUAD
• lung adenocarcinoma
• RASs
• tumorigenesis

The murine sarcoma virus oncogene (KRAS) is a key gene associated with tumorigenesis and chemotherapy resistance. However, little is known about the molecular mechanisms and immune infiltration of RASs in lung adenocarcinoma. Gene Expression Profiling Interaction Analysis was used for RASs expression analysis, and Kaplan-Meier analysis was used to analyze the potential of RASs in clinical prognosis. The effect of KRAS on immune infiltration was analyzed by TIMER. In addition, the correlation between KRAS expression and molecular mechanisms was investigated by TIMER and Cancer Single-cell State Atlas (Cancer SEA). KRAS expression levels were associated with good prognosis and tumor progression. Furthermore, KRAS expression correlates with several immune cell markers and regulates tumorigenesis. KRAS expression is involved in the regulation of multiple oncogenes and tumorigenesis, especially in the prognosis and immune infiltration of lung adenocarcinoma.

• 单位
  云南大学; 1; 6; 哈尔滨医科大学