Landscape of somatic alterations in large-scale solid tumors from an Asian population

作者：Wu, Liqun; Yao, Herui; Chen, Hui; Wang, Aodi; Guo, Kun; Gou, Wenli; Yu, Yanfei; Li, Xiang; Yao, Ming; Yuan, Shaohua; Pang, Fei; Hu, Jinwei; Chen, Lijuan; Liu, Wenjin; Yao, Jicheng; Zhang, Shuirong; Dong, Xiaowei; Wang, Weifeng; Hu, Jing; Ling, Qi; Ding, Songming; Wei, Yan; Li, Qiang; Cao, Weichun; Wang, Shuang; Di, Yang; Feng, Feiling; Zhao, Gang; Zhang, Jian; Huang, Ling; Xu, Jia; Yan, Wangjun; Tong, Zhongsheng; Jiang, Da; Ji, Tao; Li, Qiao; Xu, Ling; He, Huiying; Shang, Liang; Liu, Jin

来源：Nature Communications, 2022, 13(1): 4264.

DOI：10.1038/s41467-022-31780-9

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Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis of tumor genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tumor tissues and matched blood specimens from over 10,000 patients in China by using a 450-gene comprehensive assay, developed and implemented under international clinical regulations. We perform a comprehensive comparison of somatically altered genes, the distribution of tumor mutational burden (TMB), gene fusion patterns, and the spectrum of various somatic alterations between Chinese and American patient populations. Here, we show 64% of cancers from Chinese patients in this study have clinically actionable genomic alterations, which may affect clinical decisions related to targeted therapy or immunotherapy. These findings describe the similarities and differences between tumors from Chinese and American patients, providing valuable information for personalized medicine. @@@ Understanding the mutation landscape of cancer may enable the development of more targeted therapies. Here, the authors sequence a panel of genes in a large Asian cohort and compare to American cohorts and find 64% of the Asian patients have actionable mutations.

• 单位
  中山大学; 华中科技大学; 5; 1; 复旦大学; 青岛大学; 浙江大学; 中国医学科学院; 北京大学; 西安交通大学; 南方医科大学; 广东省人民医院; 河北医科大学; 山东大学