Effects of Vitamin D Supplementation on Disabling Foot Pain in Patients With Symptomatic Knee Osteoarthritis

Authors：Tu, Liudan; Zheng, Shuang; Cicuttini, Flavia; Jin, Xingzhong; Han, Weiyu; Zhu, Zhaohua; Antony, Benny; Winzenberg, Tania; Jones, Graeme; Gu, Jieruo; Wluka, Anita E.; Ding, Changhai^*

Source：ARTHRITIS CARE & RESEARCH, 2021, 73(6): 781-787.

DOI：10.1002/acr.24371

• MUSCULOSKELETAL PAIN
• ANKLE SYMPTOMS
• OLDER-ADULTS
• D DEFICIENCY
• PREVALENCE
• HEALTH
• QUESTIONNAIRE
• SENSITIZATION
• ASSOCIATIONS
• METAANALYSIS

Objective The present study was undertaken to determine whether vitamin D supplementation or maintaining sufficient vitamin D level reduces foot pain over 2 years in patients with symptomatic knee osteoarthritis (OA). @@@ Methods A post hoc study was conducted from a randomized, double-blind, placebo-controlled trial named the Vitamin D Effect on Osteoarthritis (VIDEO) study. Symptomatic knee OA patients with serum 25-hydroxyvitamin D levels between 12.5 nmoles/liter and 60 nmoles/liter were included and randomly allocated to either monthly vitamin D-3 or placebo treatment (1:1) for 2 years. Manchester Foot Pain and Disability Index (MFPDI) was used to evaluate foot pain and disabling foot pain was defined as at least 1 of the 10 functional limitation items (items 1-9 and 11) being documented as on "most/every day(s)" in the last month. A repeated-measures, mixed-effects model was used to analyze the change of MFPDI scores between groups adjusting for potential confounders. @@@ Results A total of 413 patients with a mean age of 63.2 years (49.7% males) were enrolled and 340 completed the study. The mean MFPDI score was 22.8 +/- 7.3, with 23.7% of participants having disabling foot pain at baseline. There were significant differences in MFPDI scores change between groups over 2 years, with more improvements in the vitamin D group than in the placebo group (-0.03 versus 1.30; P = 0.013) and more improvement in those maintaining sufficient vitamin D levels (n = 226) than those who did not (n = 114) (-0.09 versus 2.19; P = 0.001). @@@ Conclusion Vitamin D supplementation and maintenance of sufficient vitamin D levels may improve foot pain in those with knee OA.

• Institution
  中山大学; 南方医科大学