Association of unsweetened and sweetened tea consumption with the risk of new-onset chronic kidney disease: Findings from UK Biobank and Coronary Artery Risk Development in Young Adults (CARDIA) study

作者：Liu, Mengyi; Zhang, Yanjun; Ye, Ziliang; Yang, Sisi; Zhang, Yuanyuan; He, Panpan; Zhou, Chun; Hou, Fan Fan^*; Qin, Xianhui^*

来源：Journal of Global Health, 2023, 13: 04094.

DOI：10.7189/jogh.13.04094

• CYP1A2 GENOTYPE
• COFFEE
• OBESE

Background The association between tea consumption and chronic kidney disease (CKD) remained inconsistent. We aimed to evaluate the association of tea consumption with new-onset CKD and examine the effects of com-mon additives (milk and sweeteners) and genetic variations in caffeine me-tabolism on the association.Methods 176 038 and 3104 participants free of CKD at baseline in the Unit-ed Kingdom Biobank (UK Biobank) and Coronary Artery Risk Development in Young Adults (CARDIA) study were included, respectively. Dietary in-formation was collected using 24-hour dietary recall questionnaires. The study outcome was new-onset CKD.Results In the UK Biobank, during a median follow-up of 12.13 years, 3535 (2.01%) participants developed CKD. Compared with tea non-consumers, the risk of new-onset CKD was significantly lower in unsweetened tea con-sumers (hazard ratio (HR) = 0.84, 95% confidence interval (CI) = 0.76-0.93), but not in sweetened tea consumers (HR = 0.96, 95% CI = 0.85-1.08), regard-less of whether milk was added to tea. Accordingly, relative to tea non-con-sumers, the adjusted HRs (95% CIs) of new-onset CKD for participants who reported drinking unsweetened tea 1.5 or fewer, >1.5 to 2.5, >2.5 to 3.5, >3.5 to 4.5, and >4.5 drinks/d were HR = 0.86, 95% CI = 0.75-0.99; HR = 0.88, 95% CI = 0.78-1.00; HR = 0.83, 95% CI = 0.73-0.94; HR = 0.83, 95% CI = 0.72-0.95; and HR = 0.86, 95% CI = 0.75-0.99. Moreover, the as-sociation of unsweetened tea consumption with new-onset CKD was stron-ger among those with faster genetically predicted caffeine metabolism lev-els, although the interaction was insignificant (P-value interaction = 0.768). Consistently, in the CARDIA study, compared with tea non-consumers, a significantly lower risk of new-onset CKD was found in unsweetened tea consumers (HR = 0.80, 95% CI = 0.65-0.98) but not in sweetened tea con-sumers (HR = 0.97, 95% CI = 0.70-1.34).Conclusions Compared with tea non-consumers, consumption of unsweet-ened tea, but not sweetened tea, was significantly associated with a lower risk of new-onset CKD, regardless of whether milk was added.

• 单位
  南方医科大学