Interface Assembly of Polymer Networks on Metal-Organic Frameworks for the Engineering of Functional Nanoparticles

作者：Tian, Yuan; Gao, Zhiliang; Li, Mengqi; Hu, Ming; Hao, Jingcheng; Cui, Jiwei^*

来源：Chemistry of Materials, 2023, 35(14): 5593-5601.

DOI：10.1021/acs.chemmater.3c01094

• PHENOLIC CAPSULES
• PARTICLES
• MOLECULES

We report a versatile approach for the engineering offunctionalpolymer nanoparticles (NPs) with tunable sizes, stiffness, and responsivenessvia templating zeolitic imidazolate framework-8 (ZIF-8) NPs. Thismethod is applicable to various components ranging from syntheticpolymers to biomacromolecules, which are preloaded in ZIF-8 NPs andsimultaneously cross-linked during the removal of the templates undermild conditions. Different cross-linking strategies (i.e., thiol-disulfideexchange, click chemistry, amidation reaction, and Schiff base reaction)are feasible for the formation of polymer networks. The advantagesof the reported method rely on the simple assembly process, versatilityof polymer components, and good control over physicochemical propertiesof polymer NPs. The versatile assembly strategy together with thetunable functions makes the polymer NPs promising for therapeuticdelivery.

• 单位
  山东大学