Metal & Surfactant-Free oxidation of Quinoxalin-2(1H)-ones: Access to Quinoxaline-2,3-diones

作者：Li, Xuan; Zang, Jiawang; Wang, Shoucai; Kang, Chen; Xu, Jiawei; Jiang, Guangbin; Ji, Fanghua^*

来源：2022, 102: 153916.

DOI：10.1016/j.tetlet.2022.153916

• ONE-POT SYNTHESIS
• DESIGN

An efficient and direct oxidative reaction for the construction of 1,4-dihydroquinoxaline-2,3-diones has been developed. A range of oxidative products are obtained with satisfactory yields (up to 99%). This practical method features transition metal free, surfactant free, chromatography free, mild reaction conditions, good functional group tolerance and easy scale-up synthesis. Furthermore, it provided a convenient approach for the synthesis of one kind of known inhibitor for a-glucosidase. This mechanistic study shows that this transformation is not a radical process.

• 单位
  桂林理工大学