New Heterometallic Metal-organic Complex: Photocatalytic Property and Therapeutic Effect on Liver Cancer by Regulating the Mir-131 Expression

作者：Huang, Xiao-Kun; Liang, Chen; Wang, Yong-Li^*

来源：Latin American Journal of Pharmacy, 2022, 41(8): 1645-1651.

• 3D framework
• heterometallic compound
• hydrothermal synthesis
• liver cancer
• photocatalysis

A new heterometallic compound, namely [CuSr(Hbtc)(2)(H2O)(2)] n (1, H(3)btc = 1,2,4-benzenetricarboxylic acid), has been hydrothermally synthesized. It features a 3D framework based on 1D -{Cu-(COO)(2)-Sr}(n)- chains, and the Hbtc(2-) ligand in the structure of 1 shows a (x(1))-(x(1):x(1))-(x(1):x(1))-mu(5) bridging mode. The investigation of its photocatalytic behavior revealed that 1 was can be served as a stable photocatalyst for the degradation of MB under UV light irradiation. Its therapeutic effect on liver cancer was evaluated and the related mechanism was explored as well. The inhibitory activity of the new compound on the cancer cell viability was determined with CCK-8 assay. The relative expression of the miR-131 was also determined with real time RT-PCR assay.

• 单位
  南方医科大学