Influence of Changes in Obesity Indicators on the Risk of Hypertension: A Cohort Study in Southern China

作者：Peng, Xin; Huang, JunXuan; Liu, Yan; Cheng, MengJiao; Li, Bo; Li, RuiLing; Wang, PeiXi^*

来源：Annals of Nutrition and Metabolism, 2021, 77(2): 100-108.

DOI：10.1159/000515059

• Body mass index
• Cohort study
• Obesity indicators
• Hypertension

Objectives: The objective of this study was to demonstrate the association between changes in different obesity indicators and the risk of incident hypertension by the age-group among community-dwelling residents in southern China. Methods: A total of 6,959 non-hypertensive participants aged >= 18 years old were enrolled in this cohort study and completed questionnaire interviews and anthropometric measurements at baseline (2010) and follow-up (2017). A time-dependent covariate Cox proportional hazard model considered the changes in obesity indicators during the follow-up period and calculated the hazard ratios (HRs) to analyze the risk of incident hypertension according to different obesity indicators. Results: During a mean follow-up of 7.1 years, 1,904 participants were newly diagnosed with hypertension. The body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were significantly positively associated with an increased future risk of incident hypertension, and BMI was the best predictive indicator of hypertension (obesity in men: HR = 2.65, 95% confidence interval (CI) = 2.20-3.20; obesity in women: HR = 2.80, 95% CI = 2.27-3.45). Compared with the middle-aged and older group, the risk of incident hypertension was highest in the younger group which had the highest baseline obesity indicators. Conclusions: Changes in obesity indicators were significantly associated with the risk of incident hypertension in all age-groups, and the risk of future incident hypertension increased with the increase in baseline obesity indicators.

• 单位
  南方医科大学; 中山大学; 广州医学院