Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

作者：Jin, Tongxia; Cheng, Di; Jiang, Guanyu; Xing, Wenqian; Liu, Peiwen; Wang, Bin; Zhu, Weiping^*; Sun, Haitao^*; Sun, Zhenrong; Xu, Yufang; Qian, Xuhong^*

来源：Bioactive Materials, 2022, 14: 42-51.

DOI：10.1016/j.bioactmat.2021.12.009

• Near-infrared dye
• Integration strategy
• Phototherapy
• Combination therapy
• Drug delivery system

Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene and cyanine are the clinically or preclinically used photosensitizer or photothermal agents. Development of structurally diverse near-infrared dyes with long absorption wavelength is of great significance for PDT and PTT. Herein, we report a novel near-infrared dye ML880 with naphthalimide modified cyanine skeleton. The introduction of naphthalimide moiety results in stronger electron delocalization and larger redshift in emission compared with IR820. Furthermore, ML880 is co-loaded with chemotherapeutic drug into ROS-responsive mesoporous organosilica (RMON) to construct nanomedicine NBD&ML@RMON, which exhibits remarkable tumor inhibition effects through PDT/PTT/chemotherapy in vivo.

• 单位
  华东理工大学