Involucrasin C, Anti-Inflammatory 2,3-Dihydro-1H-Indene Derivative from Chinese Dai Ethnic Medicine Shuteria involucrata

Authors：Li, Xiao-Hong; Huang, Feng; Zhang, Bin-Ruo; Tan, Wen-Hong; Khan, Afsar; Zhou Zhi-Hong; Liu, Lu^*; Yang, Zhu-Ya^*

Source：CHEMISTRY & BIODIVERSITY, 2022, 19(9): e202200188.

DOI：10.1002/cbdv.202200188

• Shuteria involucrata
• 2
• 3-dihydro-1H-indene
• cytotoxic activity
• anti-inflammatory activity
• involucrasin C

(+/-)-Involucrasin C (1), a pair of new 2,3-dihydro-1H-indene enantiomers, along with an enantiomeric analog (2), were isolated from Shuteria involucrata. Their structures were established by the basis of comprehensive spectroscopic data analysis and X-ray crystallographic diffraction. Both 1 and 2 significantly inhibited the secretion of pro-inflammatory cytokines IL-6, TNF-alpha, and IL-1 beta, suggesting that these two natural 2,3-dihydro-1H-indene derivatives may be active components of S. involucrata and may block inflammation in the initial stage.

• Institution
  云南大学