MgO-incorporated porous nanofibrous scaffold promotes osteogenic differentiation of pre-osteoblasts

作者：Wang, Xiaoyu; Liu, Mingyue; Li, Haiyan; Yin, Anlin; Xia, Changlei; Lou, Xiangxin; Wang, Hongsheng; Mo, Xiumei; Wu, Jinglei^*

来源：Materials Letters, 2021, 299: 130098.

DOI：10.1016/j.matlet.2021.130098

• Biomaterials
• Magnesium oxide nanoparticles
• Biomimetic
• Scaffold
• Osteogenesis

A feasible approach to fabricate porous nanofibrous scaffolds structurally similar to native extracellular matrix was reported. Magnesium oxide (MgO) nanoparticles were incorporated into electrospun poly (lactic acid) (PLA)/gelatin membranes, which were processed into short fibers and reconstructed to three-dimensional scaffolds. The scaffold exhibited sponge-like appearance with interconnected pores ranging from 50 to 200 mm and was highly elastic. MgO nanoparticles hydrolyzed and alleviated the acidic degradation products of PLA/gelatin scaffold. Released magnesium ions were beneficial to preosteoblasts by promoting proliferation and by upregulating osteogenic differentiation, indicating that the scaffold might find opportunities for bone grafting materials.

• 单位
  南京林业大学; 东华大学; 嘉兴学院