Summary

Long noncoding RNAs (lncRNAs) have been shown to be aberrantly expressed in oral squamous cell carcinoma (OSCC), but the biological role and function of BRAF-activated long noncoding RNA (BANCR) in OSCC remain poorly understood. In this study, we found that the expression of BANCR was up-regulated in OSCC tissues and cell lines compared to the negative control. The decreased expression of BANCR in vitro markedly inhibited OSCC cell proliferation, migration, and invasion while the opposite was observed for the overexpression of BANCR. The results also showed that the expression of MAPK signaling related proteins (p-erk, p-akt and p-p-38) was positively correlated with that of BANCR. Thus, BANCR may play an important role in the tumorigenesis of OSCC, as well as cell proliferation, migration and invasion of OSCC, and it may be a potential therapeutic target and prognostic factor in OSCC patients.

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