Copper-catalyzed Reaction of Anthranils with Methyl Ketones: Site-Selective C5-Dicarbonylation of Anthranils

作者：Zhuang, Shi-Yi; Tang, Yong-Xing; He, Cai; Chen, Xiang-Long; Xue, Wei-Jian; Wu, Yan-Dong^*; Wu, An-Xin^*

来源：Advanced Synthesis and Catalysis, 2021, 363(4): 1137-1141.

DOI：10.1002/adsc.202001334

• copper-catalyzed
• site-selective
• Csp(3)-H
• Csp(2)-H cross-coupling
• 1
• 2-dicarbonyl compounds

A copper-catalyzed site-selective C5-dicarbonylation reaction of anthranils has been developed for synthesis of 1,2-dicarbonyl compounds using methyl ketone as a commercially available carbonylation reagent. This process represents the first example to implement the C5-dicarbonylation of anthranils, which involves an oxidative Csp(3)-H/Csp(2)-H cross-coupling reaction along with thermolytic N-O bond cleavage.