Research Progress on the Relationship between Cryopreservation of Mammalian Germ Cells and Their DNA Methylation

作者：CAO Jun guo; WEI Hai jun; XU Bao zeng

来源：中国畜牧兽医, 2017, 44(3).

DOI：10.16431/j.cnki.1671-7236.2017.03.028

• mammalian animal
• germ cells
• cryopreservation
• DNA methylation

Cryopreservation of mammalian germ cells and embryos has been widely used in assisted reproduction.It also plays an important role in preservation of species diversity.DNA methylation abnormality induced by freezing in germ cells or embryos has an significant impact on the occurrence of disease and the physiological function of the offspring.In this paper, we summarize the effects of cryopreservation of mammalian germ cells and embryos on their pattern of DNA methylation which in turn make the developmental deficiency in the progeny from these gametes or embryos.Finally, it will provide the reference on the gamete cryopreservation and the development of assisted reproductive technology.

• 单位
  中国农业科学院特产研究所