Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

作者：Ruan, Yongsheng^*; Chen, Libai; Xie, Danfeng; Luo, Tingting; Xu, Yiqi; Ye, Tao; Chen, Xiaona; Feng, Xiaoqin; Wu, Xuedong^*

来源：Frontiers in Endocrinology, 2022, 13: 865436.

DOI：10.3389/fendo.2022.865436

• cell adhesion-mediated drug resistance
• endocrine-related cancers
• tumor microenvironment
• cell adhesion molecules
• chemoresistance

Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial-mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.

• 单位
  南方医科大学