Inverse correlations between serum carotenoids and respiratory morbidity and mortality: the Third National Health and Nutrition Examination Survey

作者：Yang, Ruiming; Cao, Ziteng; Liu, Xin; Xiao, Mengjie; Li, Mengyao; Chen, Yunyan; Chen, Luyao; Sun, Changhao; Chu, Xia; Ren, Qiang; Wei, Wei^*

来源：British Journal of Nutrition, 2023, 130(11): 1932-1941.

DOI：10.1017/S0007114523000806

• Antioxidant
• Serum carotenoids
• Respiratory disease
• Morbidity
• Mortality

The objective was to evaluate the association between serum carotenoid levels and respiratory morbidity and mortality in a nationally representative sample of US adults. We assessed the association of serum carotenoid levels with respiratory morbidity and mortality using logistic regression and proportional hazards regression models. Meanwhile, a series of confounders were controlled in regression models and restricted cubic spline, which included age, sex, race, marriage, education, income, drinking, smoking, regular exercise, BMI, daily energy intake, vitamin E, vitamin C, fruit intake, vegetable intake, diabetes, hypertension, asthma, emphysema and chronic bronchitis. Compared with participants in the lowest tertiles, participants in the highest tertiles of serum total carotenoids, beta-cryptoxanthin and lutein/zeaxanthin levels had a significantly lower prevalence of emphysema (ORtotal carotenoids = 0 center dot 61, 95% CI: 0 center dot 41-0 center dot 89, OR beta-cryptoxanthin = 0 center dot 67, 95% CI: 0 center dot 49-0 center dot 92), chronic bronchitis (OR beta-cryptoxanthin = 0 center dot 66, 95% CI: 0 center dot 50-0 center dot 87) and asthma (Q2: ORlutein/zeaxanthin = 0 center dot 78, 95% CI: 0 center dot 62-0 center dot 97); participants in the highest tertiles of total carotenoids, alpha-carotene, lutein/zeaxanthin and lycopene had a lower risk of respiratory mortality (hazard ratio (HR)(total carotenoids) = 0 center dot 62, 95% CI: 0 center dot 42-0 center dot 90, HR alpha-carotene = 0 center dot 54, 95% CI: 0 center dot 36-0 center dot 82, HRlutein/zeaxanthin = 0 center dot 48, 95% CI: 0 center dot 33-0 center dot 71, HRlycopene = 0 center dot 66, 95% CI: 0 center dot 45-0 center dot 96) than those in the lowest tertiles. Higher serum total carotenoids and beta-cryptoxanthin levels is associated with decreased prevalence of emphysema and chronic bronchitis, and higher serum total carotenoids, alpha-carotene, lutein/zeaxanthin and lycopene levels had a lower mortality of respiratory disease.

• 单位
  1; 哈尔滨医科大学