One-year change in resting heart rate and subsequent risk of hypertension in healthy Chinese adults

作者：Li, Hanlin; Dai, Meng; Deng, Zhihui; Peng, Zhengliang; Huang, Xingfu; Bai, Yujia; Hou, Lina; Ouyang, Ping; Zhan, Qiong; Zeng, Qingchun; Xu, Dingli^*

来源：BLOOD PRESSURE MONITORING, 2021, 26(1): 39-45.

DOI：10.1097/MBP.0000000000000472

• autonomic nerve system
• hypertension
• resting heart rate
• risk factor

Background @@@ Changes in baseline resting heart rate (RHR) appear to predict new-onset hypertension (NOH). However, RHR is a dynamic anthropometric parameter; thus, the association between changes in RHR and NOH requires further investigation. @@@ Methods @@@ We studied 10 403 participants who were initially normotensive and who had at least one routine health examination at baseline and 1 year later during 2011-2016. We compared the RHR between the baseline and 1-year follow-up. We defined hypertension as SBP >= 140 mmHg or DBP >= 90 mmHg. Participants were divided into three groups: RHR decreased, RHR unchanged [from 0 to 10 beats per minute (bpm)], and RHR increased >= 10 bpm. Cox regression analysis was performed to calculate relative risk with 95% confidence intervals (CIs) for the association between NOH and RHR change. @@@ Results @@@ During a mean follow-up period of 2.42 years, 1173 (11.28%) participants developed hypertension. After adjusting for age, sex, SBP, DBP, RHR and other confounders obtained at baseline, and compared with participants with unchanged RHR, participants with decreased RHR had a 17% decreased risk of NOH (adjusted hazard ratio: 0.83, 95% CI 0.73-0.95), whereas subjects with RHR that increased >= 10 bpm had a 23% increased risk of NOH (adjusted hazard ratio: 1.23, 95% CI 1.04-1.46). @@@ Conclusion @@@ A 1-year increase in RHR for initially normotensive subjects is an independent risk factor for subsequent hypertension.

• 单位
  南方医科大学