Association of lipoprotein(a) with aortic dissection

作者：Yang, Yiheng; Hong, Yuting; Yang, Weihua^*; Zheng, Zhenzhong^*

来源：Clinical Cardiology, 2022, 45(9): 908-912.

DOI：10.1002/clc.23834

• aortic dissection
• case-control study
• lipoprotein(a) [Lp(a)]

Background Lipoprotein(a) [Lp(a)] is associated with coronary atherosclerotic heart disease, aortic stenosis, stroke, and heart failure. We aimed to determine the relationship between Lp(a) and aortic dissection (AD). Methods Two hundred patients with AD were included in our case group. The control group consisted of 200 non-AD people who were age- (+/- 5 years) and gender-matched to the case group. Data were collected retrospectively, including hypertension, smoking, coronary artery disease, diabetes mellitus, Lp(a), total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. The association between Lp(a) and AD was studied using univariate and multivariate logistic regression analysis. Results Patients with AD had greater median Lp(a) concentrations than non-AD people (152.50 vs. 81.75 mg/L). Lp(a) was associated with AD in a multivariate logistic regression analysis (odds ratio, 8.03; 95% confidence interval, 2.85-22.62), comparing those with Lp(a) quartile 4 with those with Lp(a) quartile 1. Stratified analysis showed that this relationship was observed in both men and women, as well as in older and younger individuals. Conclusions High levels of Lp(a) are strongly associated with AD, independent of other cardiovascular risk factors.

• 单位
  南昌大学; 1