Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma

Authors：Li, Di; Xu, Weiguo; Li, Pengqiang; Ding, Jianxun^*; Cheng, Zhihang; Chen, Li; Yan, Lesan^*; Chen, Xuesi

Source：MOLECULAR PHARMACEUTICS, 2016, 13(12): 4231-4235.

DOI：10.1021/acs.molpharmaceut.6b00747

• polysaccharide
• prodrug
• self-targetability
• orthotopic hepatoma
• chemotherapy

Self-targetability is an emerging targeting strategy for polymer nanocarriers with facile preparation and high targeting efficiency. An acid-sensitive dextran doxorubicin prodrug (Dex-g-DOX) has been synthesized and used as a self-targeted drug delivery system for the treatment of orthotopic hepatoma. The polysaccharide prodrug exhibits ultraselective accumulation in cancerous liver tissue, acid-sensitive DOX release within cells, and high antitumor efficacy in vitro and in vivo. Therefore, Dex-g-DOX demonstrates great potential for chemotherapy of orthotopic hepatoma.