A multifunctional cascade nanoreactor based on Fe-driven carbon nanozymes for synergistic photothermal/chemodynamic antibacterial therapy

作者：Shen, Yizhong; Nie, Chao; Pan, Ting; Zhang, Wei^*; Yang, Hui; Ye, Yingwang^*; Wang, Xianwen^*

来源：Acta Biomaterialia, 2023, 168: 580-592.

DOI：10.1016/j.actbio.2023.07.006

• Diabetic wound healing
• Nanozyme
• Cascade
• Chemodynamic therapy
• Photothermal therapy

Statement of significance An all-in-one glucose-responsive photothermal nanozyme GOX/MPDA/Fe@CDs was constructed. Cascade nanozyme GOX/MPDA/Fe@CDs self-supply H2O2 and H + to break H2O2 and pH limits to fight bacte-rial infections. Synergistic chemotherapy and photothermal therapy with nanozyme GOX/MPDA/Fe@CDs accelerates healing of biofilm-infected diabetic wounds.& COPY; 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.Statement of significanceAn all-in-one glucose-responsive photothermal nanozyme GOX/MPDA/Fe@CDs was constructed. Cascade nanozyme GOX/MPDA/Fe@CDs self-supply H2O2 and H + to break H2O2 and pH limits to fight bacte-rial infections. Synergistic chemotherapy and photothermal therapy with nanozyme GOX/MPDA/Fe@CDs accelerates healing of biofilm-infected diabetic wounds.& COPY; 2023 Acta Materialia Inc. Published by Elsevier Ltd.

• 单位
  安徽医科大学