3D printing and physicochemical and biological characterizations of gallium-containing magnesium/calcium phosphate ceramic scaffolds

作者：He, Fupo^*; Rao, Jin; Fu, Wenhao; Zhou, Jielin; Zhang, Yuxuan; Chen, Tengyun; Huang, Wenhao; Wang, Yao; Lu, Teliang^*; Shi, Haishan^*

来源：Ceramics International, 2023, 49(21): 34173-34181.

DOI：10.1016/j.ceramint.2023.08.127

• Magnesium phosphate
• Ceramic scaffolds
• Gallium
• Calcium phosphate
• 3D printing

In this study, gallium-containing magnesium/calcium phosphate ceramic scaffolds (G-MCP) were prepared by sintering the mixtures of gallium-doped tricalcium phosphate and trimagnesium phosphate at low temperatures (950 and 1000 degrees C), and their pore structure was formed by the extrusion-type 3D printing method. The G-MCP ceramic scaffolds were dominated by the gallium/magnesium-doped Ca3Mg3(PO4)4 phase. The G-MCP ceramic scaffolds sintered at 950 degrees C attained considerably high compressive strength (5.0-13.2 MPa) as well as porosity (63.7%-72.1%). When the sintering temperature increased to 1000 degrees C, the G-MCP ceramic scaffolds achieved tremendous increase in compressive strength (38.3-94.3 MPa), which was concomitant with significant decrease in porosity (46.2%-48.7%). Benefiting from the release of gallium, magnesium and calcium ions, the G-MCP ceramic scaffolds noticeably stimulated in vitro cell growth and osteoblastic differentiation, and distinctively obstructed the osteoclastic differentiation. The G-MCP ceramic scaffolds are promising for effectively treating the osteoporotic bone defects.

• 单位
  广东省人民医院; 广东工业大学; 南方医科大学