Tissue clearing to examine glioma complexity in 3 dimensions

作者：Yang, Xinyi; Ye, Zhaoyu; Zhang, Minglin; Ouyang, Ye; He, Dian; Wang, Xinyue; Lai, Hei Ming; Sun, Haitao^*

来源：Journal of Neuropathology and Experimental Neurology, 2023, 82(5): 376-389.

DOI：10.1093/jnen/nlad024

• 3D visualization
• Glioblastoma
• Glioma invasion
• Glioma stem cell
• Tissue clearing
• Tumor microenvironment

In recent years, tissue clearing has revolutionized the way we view biological materials. This has resulted in considerable advances in neuropathology and brain imaging. Its application to gliomas has the potential to increase understanding of tumor architecture, reveal mechanisms of tumor invasion, and provide valuable insights into diagnostics and treatments. This review outlines numerous tissue-clearing applications and recent developments in glioma research and delineates the limitations of existing technology and potential applications in experimental and clinical oncology.

• 单位
  南方医科大学