J-shaped association between dietary copper intake and all-cause mortality: a prospective cohort study in Chinese adults

作者：Gan, Xiaoqin; He, Panpan; Zhou, Chun; Zu, Cheng; Meng, Qiguo; Liu, Mengyi; Zhang, Yuanyuan; Yang, Sisi; Zhang, Yanjun; Ye, Ziliang; Wu, Qimeng; Li, Rui; Liu, Chengzhang^*; Qin, Xianhui^*

来源：British Journal of Nutrition, 2023, 129(11): 1841-1847.

DOI：10.1017/S0007114522002732

• Dietary copper intake
• All-cause mortality
• General Chinese adults
• China Health and Nutrition Survey
• J-shape

The association between dietary Cu intake and mortality risk remains uncertain. We aimed to investigate the relationship of dietary Cu intake with all-cause mortality among Chinese adults. A total of 17 310 participants from the China Health and Nutrition Survey, a national ongoing open cohort of Chinese participants, were included in the analysis. Dietary intake was measured by three consecutive 24-h dietary recalls in combination with a weighing inventory over the same 3 d. The average intakes of the 3-d dietary macronutrients and micronutrients were calculated. The study outcome was all-cause mortality. During a median follow-up of 9 center dot 0 years, 1324 (7 center dot 6 %) participants died. After adjusting for sex, age, BMI, ever alcohol drinking, ever smoking, education levels, occupations, urban or rural residents, systolic blood pressure, diastolic blood pressure and the intakes of fat, protein and carbohydrate, the association between dietary Cu intake and all-cause mortality followed a J-shape (P (for nonlinearity) = 0 center dot 047). When dietary Cu intake was assessed as quartiles, compared with those in the first quartile (<1 center dot 60 mg/d), the adjusted hazard ratios for all-cause mortality were 0 center dot 87 (95 % CI (0 center dot 71, 1 center dot 07)), 0 center dot 98 (95 % CI (0 center dot 79, 1 center dot 21)) and 1 center dot 49 (95 % CI (1 center dot 19, 1 center dot 86)), respectively, in participants in the second (1 center dot 60-<1 center dot 83 mg/d), third (1 center dot 83-<2 center dot 09 mg/d) and fourth (>= 2 center dot 09 mg/d) quartiles. A series of subgroup analyses and sensitivity analyses showed similar results. Overall, our findings emphasised the importance of maintaining optimal dietary Cu intake levels for prevention of premature death.

• 单位
  安徽医科大学; 南方医科大学