Regio- and Stereoselective Hydrochlorination/Cyclization of 1,n-Enynes by FeCl3 Catalysis

作者：Hou, Jicheng; Yin, Junhao; Han, Hao; Yang, Qirui; Li, Yougui^*; Lou, Yazhou^*; Wu, Xiang; You, Yang'en^*

来源：Organic Letters, 2023, 25(23): 4359-4365.

DOI：10.1021/acs.orglett.3c01495

• IRON CATALYSIS
• OXIDATIVE CYCLIZATION
• COUPLING REACTIONS
• VINYL CHLORIDES
• ARYL
• INACTIVATION
• DERIVATIVES
• ANNULATION
• 1,6-ENYNES
• DEUTERIUM

A highly regio- and stereoselective hydrochlorination/cyclizationof enynes has been reported by FeCl3 catalysis. A varietyof enynes undergo this cyclization transformation with acetic chlorideas the chlorine source and H2O providing protons via acationic pathway. This protocol provides a cheap, simple, stereospecific,and effective cyclization to afford heterocyclic alkenyl chloridecompounds as Z isomers with high yields (<= 98%)and regioselectivity.

• 单位
  安徽医科大学