Effect of humidified high-flow nasal cannula oxygen therapy on respiratory function recovery in stable COPD patients

作者：Lyu, Ruibing; Wang, Wen; Wang, Wenju; Liu, Nian; Xiao, Jinwen; Lil, Xin^*

来源：American Journal of Translational Research, 2022, 14(6): 4074-4081.

• HFNC
• stable COPD
• respiratory function recovery
• 6MWT

Objective: To investigate the effect of humidified high-flow nasal cannula oxygen therapy (HFNC) on the application effect and respiratory functional recovery of stable COPD patients. Methods: The data of 116 patients with stable COPD treated in our hospital from March 2019 to January 2021 were analyzed retrospectively. Among them, 54 patients treated with conventional oxygen therapy (COT) were enrolled into the control group (CG), and the remaining 62 treated with HFNC were divided to the experimental group (EG). The clinical efficacy and adverse reactions of both groups were assessed, and the blood gas analysis indexes pH, PaO2, PaCO2, respiratory function indexes FEV1, FEV1%, FEV1/FVC, quality of life and motor recovery were compared. Results: After treatment, compared with the CG, the FEV1, FEV1% and FEV1/FVC in the EG were obviously higher (P<0.05). Besides, the pH and PaO2 in the EG were markedly higher (P<0.05), while PaCO2 was lower (P<0.05). The total effective rate, SGRQ scores and 6MWT in the EG were markedly higher than those in the CG (P<0.05), while the incidence of adverse reactions in the EG was lower (P<0.05). Conclusion: HFNC can improve respiratory function and quality of life of stable COPD patients, with higher safety.