Macrophages in periodontitis: A dynamic shift between tissue destruction and repair

作者：Yin, Linying; Li, Xinzhu^*; Hou, Jin^*

来源：Japanese Dental Science Review, 2022, 58: 336-347.

DOI：10.1016/j.jdsr.2022.10.002

• Macrophages
• Periodontitis
• Dysbiosis
• Oral microbiome
• Inflammation

Periodontitis is a chronic inflammatory disease associated with a dysbiotic bacterial biofilm in the sub -gingival environment that may disturb the balance between the oral microbiome and its host. The inability of the immune system to eliminate inflammation may result in the progressive destruction of tooth-support tissues. Macrophages are crucial cellular components of the innate immune system and play important roles in diverse physiological and pathological processes. In response to periodontitis-associated bacterial communities, macrophages contribute to inflammation and restoration of tissue homeostasis through pattern recognition receptor-induced signaling cascades; therefore, targeting macrophages can be a feasible strategy to treat patients with periodontitis. Although recent studies indicate that macrophages have a spectrum of activation states, ranging from pro-inflammatory to anti-inflammatory, the regulatory me-chanism of the macrophage response to dysbiosis in a tissue-specific manner remains largely unclear. Herein, we attempt to summarize the potential role of macrophage activation in the progression of peri-odontitis, as well as its relevance to future approaches in the treatment of periodontitis.(c) 2022 Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

• 单位
  南方医科大学