Altered B cell immunoglobulin signature exhibits potential diagnostic values in human colorectal cancer

作者：Liu, Rui-Xia; Wen, Chuangyu; Ye, Weibiao; Li, Yewei; Chen, Junxiong; Zhang, Qian; Li, Weiqian; Liang, Wanfei; Wei, Lili; Zhang, Jingdan; Chan, Ka-Wo; Wang, Xueqin; Yang, Xiangling^*; Liu, Huanliang^*

来源：iScience, 2023, 26(3): 106140.

DOI：10.1016/j.isci.2023.106140

• CLASS SWITCH RECOMBINATION
• SOMATIC HYPERMUTATION
• IGG
• PLASMABLASTS
• LYMPHOCYTES
• SURVIVAL
• BACTERIA

Antibody-secreting B cells have long been considered the central element of gut homeostasis; however, tumor-associated B cells in human colorectal cancer (CRC) have not been well characterized. Here, we show that the clonotype, phenotype, and immunoglobulin subclasses of tumor-infiltrating B cells have changed compared to adjacent normal tissue B cells. Remarkably, the tumor-associated B cell immunoglobulin signature alteration can also be detected in the plasma of patients with CRC, suggesting that a distinct B cell response was also evoked in CRC. We compared the altered plasma immunoglobulin signature with the ex-isting method of CRC diagnosis. Our diagnostic model exhibits improved sensi-tivity compared to the traditional biomarkers, CEA and CA19-9. These findings disclose the altered B cell immunoglobulin signature in human CRC and highlight the potential of using the plasma immunoglobulin signature as a non-invasive method for the assessment of CRC.

• 单位
  南方医科大学; 6; 中山大学