Real-Time Micromotor Probe for Immune Neutrophil Activation State

作者：Fu, Dongmei; Jiang, Jiamiao; Fu, Shaoming; Xie, Dazhi; Gao, Chao; Feng, Ye; Liu, Suyi; Ye, Yicheng; Liu, Lu; Tu, Yingfeng^*; Peng, Fei

来源：Advanced Healthcare Materials, 2023, 12(24).

DOI：10.1002/adhm.202300737

• biomechanical probes
• magnetic actuation
• neutrophil activation states
• Spirulina micromotors

Neutrophil activation is a hallmark of the immune response. Approaches to identify neutrophil activation in real time are necessary but are still lacking. In this study, magnetic Spirulina micromotors are used as label-free probes that exhibit differences in motility under different neutrophil activation states. This is correlated with different secretions into the extracellular environment by activated/non-activated cells and local environmental viscoelasticity. The micromotor platform can bypass non-activated immune cells while being stopped by activated cells. Thus, the micromotors can serve as label-free biomechanical probes of the immune cell state. They can detect the activation state of target immune cells in real time and with single-cell precision, which provides new ideas for the diagnosis and treatment of diseases while deepening understanding of the biomechanics of activated immune cells.

• 单位
  南方医科大学; 中山大学