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摘要
Objective: to explore the relationship between the expres-sion of DEAH-box RNA helicase 15 (DHX15) in colorectal cancer (CRC), its clinical pathological features and survival.Method: DHX15 expression data with clinical pathological features from the Cancer Gene Atlas (TCGA) and the Clini-cal Proteomic Tumor Analysis Consortium (CPTAC) were sta-tistically analyzed for the association between DHX15 ex-pression and overall survival in CRC. The expression of DHX15 was performed by immunohistochemical staining (IHC) using tumor and the adjacent normal tissue, mounted in tissue microarrays. The significance of DHX15 expression to predict survival and prognosis of CRC were analyzed us-ing the Kaplan-Meier method, univariate and multivariate Cox regression analysis.Results: low expression of DHX15 mRNA and DHX15 protein in CRC were both negative factors for survival. Overall survival of patients with low-expression of DHX15 was significantly lower (x2 = 8.452, p = 0.004) by Kaplan-Meier evaluation. Low expression of DHX15 in CRC tissues correlated with distal lymph node metastasis (x2 = 7.120, p = 0.008), TNM stage (x2 = 3.935, p = 0.047) and disease recurrence (x2 = 9.524, p = 0.002) in CRC. Low expression of DHX15 (HR = 4.012, 95 % CI: 1.462-11.013, p = 0.007), late TNM stage (HR = 0.067, 95 % CI: 0.029-0.156, p < 0.001) and recurrence (HR = 0.008, 95 % CI: 0.002-0.034, p < 0.001) were risk factors related to the prognosis of CRC patients by univariate Cox regression analysis.Conclusion: our findings reveal a key role for DHX15 in the progress of CRC metastasis and recurrence. DHX15 may be a potential biomarker for CRC targeted therapy.
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单位y; 哈尔滨医科大学
