Covalent organic framework-loaded silver nanoparticles as robust mimetic oxidase for highly sensitive and selective colorimetric detection of mercury in blood

作者：Liu, Qingqing; Xu, Chenchen; Chu, Su; Li, Shuai; Wang, Fengxiang; Si, Yanmei; Mao, Guojiang; Wu, Choufei; Wang, Hua^*

来源：Journal of Materials Chemistry B, 2022, 10(48): 10075-10082.

DOI：10.1039/d2tb01887j

• IONS
• HG2+
• ULTRAFINE

Covalent organic frameworks (COFs) were fabricated with a hierarchical flower-like hollow structure, possessing a large specific surface area, high porosity, and excellent environmental stability. In situ growth of noble silver nanoparticles (AgNPs) onto COFs was conducted yielding COF-Ag nanozymes. The structural advantages of COFs can ensure the uniform dispersion and effective size control of AgNPs. More interestingly, the oxidase-like catalytic activity of the obtained COF-Ag nanozymes could be enhanced in the presence of Hg2+ ions, which could specifically interact with AgNPs to form Ag-Hg alloys. A COF-Ag catalysis-based colorimetric platform was thereby constructed for highly selective and sensitive analysis of Hg2+ ions, showing a linear concentration range from 0.050 to 10.0 mu M, with a limit of detection of about 3.7 nM. Besides, the developed colorimetric strategy was successfully applied for detecting Hg2+ ions in human blood with favorable detection recoveries, indicating its potential for applications in the biomedical analysis, environmental monitoring, and food safety fields.

• 单位
  南昌航空大学