Low rectus femoris mass index is closely associated with diabetic peripheral neuropathy

作者：Wang, Lina; Lin, Xiaopu; Huang, Haishan; Wang, Yanfang; Liang, Xinxin; Zheng, Xiaobin; Xu, Lingling^*

来源：Frontiers in Endocrinology, 2023, 14: 1148093.

DOI：10.3389/fendo.2023.1148093

• diabetic peripheral neuropathy
• sarcopenia
• rectus femoris cross-sectional area
• rectus femoris mass index
• ultrasound

Aims: To assess the association of rectus femoris mass index (RFMI) with diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes mellitus (T2DM). @@@ Methods: Totally 948 T2DM cases were enrolled. Nerve conduction parameters, quantitative sensory threshold and rectus femoris cross-sectional area (RFCSA) were obtained, and rectus femoris mass index (RFMI=RFCSA/height(2)) was derived. The patients were assigned to four groups based on interquartile spacing of RFMI. @@@ Results: Motor/sensory nerve amplitude and conduction velocity (CV) were significantly lower in the low-level RFMI groups (all P<0.05). RFMI was positively associated with mean motor/sensory nerve amplitude and CV (both P<0.05). T2DM duration above 10 years and RFMI below 2.37cm(2)/m(2) had significant associations with DPN (both P<0.001). Receiver operating characteristic (ROC) curve analysis demonstrated cutoffs for T2DM duration and RFMI of 7 years and 2.2 cm(2)/m(2), respectively (AUC=0.75, 95% CI: 0.72-0.79; sensitivity, 68.4%; specificity, 66.8%). @@@ Conclusion: DPN is significantly associated with reduced RFMI in T2DM patients. Decreased muscle mass seems to be associated with motor/sensory nerve amplitude and CV. RFMI combined with T2DM duration may represent a potent tool for predicting DPN occurrence in T2DM cases.

• 单位
  南方医科大学