Reduced interpersonal neural synchronization in right inferior frontal gyrus during social interaction in participants with clinical high risk of psychosis: An fNIRS-based hyperscanning study

作者：Wei, Yanyan; Liu, Jieqiong; Zhang, Tingyu; Su, Wenjun; Tang, Xiaochen; Tang, Yingying; Xu, Lihua; Qian, Zhenying; Zhang, Tianhong; Li, Xianchun^*; Wang, Jijun^*

来源：PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2023, 120: 110634.

DOI：10.1016/j.pnpbp.2022.110634

• Clinical high risk of psychosis
• Functional near -infrared spectroscopy
• Hyperscanning
• Inter -brain neural synchronization
• Cooperation

Background: Clinical high risk (CHR) of psychosis is characterized by cognitive impairment in social interaction. However, research investigating the neurobiological underpinnings of social interactions and interpersonal re-lationships in CHR participants is sparse.Methods: 21 CHR and 54 healthy controls (HCs) participated in the study. Dyads were formed between one CHR, one sex-matched HC, and two sex-matched HCs comprising 19 CHR-HC dyads and 19 HC-HC dyads. The con-centration changes of oxyhemoglobin and deoxyhemoglobin were examined during a two-block button-press "cooperation" and "competition" task using functional near-infrared spectroscopy(fNIRS) hyperscanning tech-nology. CHR diagnosis and psychopathological assessments were performed by Structured Interview for Pro-dromal Syndromes (SIPS) and Scale of Prodromal Symptoms (SOPS). Neural synchronizations were compared between CHR-HC dyads and HC-HC dyads. Correlation analyses were performed to identify the relationship between neural synchronization, clinical syndrome and cognition.Results: During the cooperation, but not the competition task, the CHR-HC dyads showed reduced inter-brain neural synchronization (INS) in the right inferior frontal gyrus (IFG) compared to the HC-HC dyads. INS also showed a positive correlation with the average cooperation rate. Moreover, the reduced INS in the CHR-HC group was significantly correlated with symptoms score of suspiciousness/persecutory ideas and movement disorders.Conclusions: The decreased INS in right IFG during cooperation could account for CHR's cognitive impairment of social interaction. Our findings provide evidence that inter-brain neural synchronization potentially represents a biomarker of social interaction deficits of CHR.

• 单位
  上海交通大学