Advances in the study of the molecular biological mechanisms of radiation-induced brain injury

作者：Gan, Chen; Li, Wen; Xu, Jian; Pang, Lulian; Tang, Lingxue; Yu, Sheng; Li, Anlong; Ge, Han; Huang, Runze; Cheng, Huaidong^*

来源：American Journal of Cancer Research, 2023, 13(8): 3275-3299.

• Brain injury
• ionizing radiation
• exosomes
• neuroinflammation
• blood-brain barrier

Radiation therapy is one of the most commonly used treatments for head and neck cancers, but it often leads to radiation-induced brain injury. Patients with radiation-induced brain injury have a poorer quality of life, and no effective treatments are available. The pathogenesis of this condition is unknown. This review summarizes the molecular biological mechanism of radiation-induced brain injury and provides research directions for future studies. The molecular mechanisms of radiation-induced brain injury are diverse and complex. Radiation-induced chronic neuroinflammation, destruction of the blood-brain barrier, oxidative stress, neuronal damage, and physiopathological responses caused by specific exosome secretion lead to radiation-induced brain injury.

• 单位
  安徽医科大学; 南方医科大学