Implantable celecoxib nanofibers made by electrospinning: fabrication and characterization

Authors：Lu, Geng; Yang, Chuangzan; Chu, Kedi; Zhu, Yi; Huang, Sa; Zheng, Juying; Jia, Huanhuan^*; Ban, Junfeng^*; Li, Xiaofang^*

Source：Nanomedicine, 2024.

DOI：10.2217/nnm-2023-0314

• celecoxib
• electrospinning
• implantable drug-delivery system
• osteoarthritis

Background: Osteoarthritis causes tremendous damage to the joints, reducing the quality of life and imposing significant financial burden. An implantable drug-delivery system can improve the symptomatic manifestations with low doses and frequencies. However, the free drug has short retention in the joint cavity. Materials & methods: This study used electrostatic spinning technology to create an implantable drug-delivery system loaded with celecoxib (celecoxib nanofibers [Cel-NFs]) to improve retention and bioavailability. Results: Cel-NFs exhibited good formability, hydrophilicity and tensile properties. Cel-NFs were able to continuously release drugs for 2 weeks and increase the uptake capacity of Raw 264.7 cells, ultimately ameliorating symptoms in osteoarthritis rats. Conclusion: These results suggest that Cel-NFs can effectively ameliorate cartilage damage, reduce joint pain and alleviate osteoarthritis progression.

• Institution
  广东药学院