A New Chloro-Containing γ-Butyrolactone from the Mangrove Endophytic Fungus Neofusicoccum parvum Y2NBKZG1016

作者：Xie, Xiaoting; Xiao, Suping; Liao, Huiyi; Jiang, Qingjian; Chen, Gang^*; Wen, Lu^*

来源：Chemistry of Natural Compounds, 2023, 59(3): 424-427.

DOI：10.1007/s10600-023-04015-6

• Mangrove endophytic fungus
• Neofusicoccum parvum
• secondary metabolites
• otoprotective activity

A new chloro-containing gamma-butyrolactone derivative 1, together with eight known metabolites (2-9), were isolated from the mangrove endophytic fungus Neofusicoccum parvum Y2NBKZG1016. Its structure was identified as (4S,5S,6S,7R)-4-(3-chloro-1,2-dihydroxybutyl)-butyrolactone (1) by spectral data and chemical method. The otoprotective effects of all compounds and the ability of 1 to inhibit the release of lipopolysaccharide (LPS)-induced nitric oxide (NO) from RAW264.7 were determined.

• 单位
  广东药学院