Fate of bladder cancer cells controlled by surface chemistry

作者：Huang, Denggao; Cao, Hui; Guo, Lifang; Gao, Yuanhui; Zheng, Linlin; Wen, Xiaohong; Yu, Xiaolong^*; Zhang, Shufang^*

来源：Materials Letters, 2019, 256: UNSP 126661.

DOI：10.1016/j.matlet.2019.126661

• Biomaterials
• Bladder cancer cells
• Self-assembled monolayer
• Proliferation
• Apoptosis
• Adhesion

A new way for prognosis of bladder cancer (BC) is to control the BC microenvironment by chemical groups. The self-assembled monolayer (SAM) surfaces with methyl (-CH3), hydroxyl (-OH) and carboxyl (-COOH) groups were prepared to control the UMUC-3 cells. The results indicated that all three kinds of chemical groups influenced the adhesion and the proliferation of UMUC-3 cells, and the apoptosis rate of UMUC-3 cells was the highest on the -CH3 surface, which inhibited the proliferation of UMUC-3 cells.

• 单位
  中南大学; 海南大学