Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient

Sun, Jing; Zhu, Airu; Li, Heying; Zheng, Kui; Zhuang, Zhen; Chen, Zhao; Shi, Yongxia; Zhang, Zhaoyong; Chen, Si-bei; Liu, Xuesong; Dai, Jun; Li, Xiaobo; Huang, Shuxiang; Huang, Xiaofang; Luo, Ling; Wen, Liyan; Zhuo, Jianfen; Li, Yuming; Wang, Yanqun; Zhang, Lu; Zhang, Yanjun; Li, Fang; Feng, Liqiang; Chen, Xinwen; Zhong, Nanshan; Yang, Zifeng^*; Huang, Jicheng^*; Zhao, Jincun^*; Li, Yi-min

Science Citation Index Expanded

广州医学院; 中国科学院; 1

摘要

SARS-CoV-2 caused a major outbreak of severe pneumonia (COVID-19) in humans. Viral RNA was detected in multiple organs in COVID-19 patients. However, infectious SARS-CoV-2 was only isolated from respiratory specimens. Here, infectious SARS-CoV-2 was successfully isolated from urine of a COVID-19 patient. The virus isolated could infect new susceptible cells and was recognized by its' own patient sera. Appropriate precautions should be taken to avoid transmission from urine.

关键词

COVID-19 urine transmission SARS-CoV-2 virus isolation