In Vivo Aggregation of Clearable Bimetallic Nanoparticles with Interlocked Surface Motifs for Cancer Therapeutics Amplification

作者：Tan, Yue; Huang, Di; Luo, Caiming; Tang, Jiahao; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Sun, Jianwei; Liu, Jinbin^*; Tang, Ben Zhong^*

来源：Nano Letters, 2023.

DOI：10.1021/acs.nanolett.3c02399

• clearable bimetallic nanoparticle
• interlocked surfacemotifs
• aggregation-induced emission
• reactive oxygenspecies
• cancer therapeutics amplification

Although renal-clearable luminescent metal nanoparticles(NPs)have been widely developed, their application to efficient cancertherapy is still limited due to low reactive oxygen species (ROS)production. Here, a novel system of clearable mercaptosuccinic acid(MSA) coated Au-Ag bimetallic NPs is designed to enhance ROSproduction. The results show that the strong COO-Ag coordinationbonds between the carboxylic acid groups of MSA and Ag atoms on theAu-Ag bimetallic NPs could construct high-rigidity interlockedsurface motifs to restrict the intrananoparticle motions for enhancedROS generation. Moreover, bimetallic NPs exhibit pH-responsive self-assemblycapability under the acidic environment inside lysosomes of cancercells at both in vitro and in vivo, restricting the internanoparticle motions to further boost ROSproduction. The well-designed bimetallic NPs show high tumor targetingefficiency, fast elimination from the body through rapid liver biotransformation,and extensive destruction to cancer cells, resulting in good securityand prominent therapeutic performance.